Established by mission-minded Christians who called themselves Conservative Baptists, the new Mission adopted the name of the Conservative Baptist Home Mission Society. Headquarters were established in the Chicago area.

Robert and Winifred Johnson — were appointed on October 7, 1948, for ministry in Alaska. Early ministries were also launched among Jewish people, Native Americans, Chinese and Hispanics in the United States.

Soon missionaries were sent to Honduras, Mexico, Costa Rica and French Canada. U.S. ministries were developed to focus upon suburban and rural church planting, ministry among Mormons in Utah, urban ministry in major cities across the country, and campus ministry among students at secular colleges and universities. Later campus ministry expanded to internationals, effectively reaching students from around the world, many from nations where missionaries are restricted.

The name of the Mission was changed to Mission to the Americas in 1994. By this time ministry had been launched in Belize, Guatemala, and the Dominican Republic. In the 1990s the Mission began to facilitate partnership connections between U.S. churches and sister churches in Latin America and Cambodia. In 1996 ministry was initiated in El Salvador and Nicaragua and, soon after, in Haiti.

In addition to expansion, the missionary family began to grow significantly in ethnic diversity, with more than 30 percent non-Anglo missionaries by the year 2000. African Americans, Hispanic-Americans and Native Americans were added to the missionary family. Immigrants from Brazil, Cambodia, China, Cuba, Liberia, and the Philippines were appointed as missionaries to reach immigrant communities in the U.S. In our international ministries outside of the U.S., God raised up missionaries who were Belizeans, Dominicans, Haitians, Hondurans, Guatemalans, Mexicans and Quebecois. The Mission had become international, not just in its ministry focus but in the composition of its missionary family!

The Mission relocated in 2001 to the inner city neighborhood of Five Points in Denver, Colorado and changed its name in 2007 to become Missions Door. The new name was chosen to reflect ministry among immigrants in the U.S. that resulted in the development of ministry back to home countries in Asia and Africa — from there to here and back! Plus, ministries were developing beyond North America in Cambodia, China, Kenya, and Liberia.